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Variation in FTO contributes to childhood obesity and severe adult obesity

Creator:

Dina, C. et al

Subject Keywords: Study of genetic factors linked to early onset and severe obesity
Set: Obesity
Type: Report
Region: International (other)
Description:

The authors identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. They conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

Date:

13/05/2007

Rights: © Dina, C. et al
Suggested citation:

Dina, C. et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity [Online]. Available from: http://www.thehealthwell.info/node/3959 [Accessed: 25th September 2018].

  

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