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Thromboprophylaxis for trauma patients


Barrera, L.M., et al

Subject Keywords: To assess the effects of thromboprophylaxis in trauma patients on mortality and incidence of deep vein thrombosis and pulmonary embolism. To compare the effects of different thromboprophylaxis interventions and their effects according to the type of trauma
Type: Article
Region: International (other)

Thromboembolism (unwanted clotting of the blood) is a frequent complication in people who have experienced physical trauma and is also an important cause of death. The type of trauma, association with vascular injuries, and prolonged hospital bed rest are known risk factors for the development of deep vein thrombus (clot in veins of lower extremities) that can travel (embolize) to the lungs and cause death. Because of this it is usually recommended that people who have had major trauma are given mechanical or pharmacological treatments to prevent their blood forming unwanted blood clots. Mechanical interventions can include compression stockings, an air-filled plastic tube that presses around the leg, a metal blood clot filter placed inside a vein; pharmaceutical drugs include unfractionated heparin, low weight molecular heparin, anticoagulants (e.g. warfarin), antiplatelet drugs (e.g. aspirin) and others. Sixteen studies involving 3,005 people are included in this review. We did not find strong evidence that either mechanical or pharmacological interventions reduce death or clots travelling to the lungs, but we found some evidence that they can prevent clots from forming in the legs.



Rights: © The Cochrane Collaboration
Suggested citation:

Barrera, L.M., et al. (2013) Thromboprophylaxis for trauma patients [Online]. Available from: [Accessed: 20th April 2018].


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