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Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents...

Creator:

BMJ

Type: Report
Region: Republic of Ireland
Northern Ireland
Description:

1 Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Japan, 2 Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Japan, 3 Department of Immunology, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture, Japan, 4 Kinan General Hospital, Minamimuro, Mie, Japan, 5 Division of Hematology, Stanford School of Medicine, Stanford, CA, USA, 6 Department of Medicine, Winthrop University Hospital, Mineola, NY, USA Correspondence to: E C Gabazza gabazza@doc.medic.mie-u.ac.jp AbstractIntroductionMethodsResultsDiscussionReferencesObjectiveTo determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk of pneumococcal pneumonia. Design Prospective, randomised, placebo controlled double blind study. Setting Nursing homes in Japan. Participants 1006 nursing home residents. Interventions Participants were randomly allocated to either 23-valent pneumococcal polysaccharide vaccine (n=502) or placebo (n=504). Main outcome measures The primary end points were the incidence of all cause pneumonia and pneumococcal pneumonia. Secondary end points were deaths from pneumococcal pneumonia, all cause pneumonia, and other causes. Results Pneumonia occurred in 63 (12.5%) participants in the vaccine group and 104 (20.6%) in the placebo group. Pneumococcal pneumonia was diagnosed in 14 (2.8%) participants in the vaccine group and 37 (7.3%) in the placebo group (P<0.001). All cause pneumonia and pneumococcal pneumonia were significantly more frequent in the placebo group than in the vaccine group: incidence per 1000 person years 55 v 91 (P<0.0006) and 12 v 32 (P<0.001), respectively. Death from pneumococcal pneumonia was significantly higher in the placebo group than in the vaccine group (35.1% (13/37) v 0% (0/14), P<0.01). The death rate from all cause pneumonia (vaccine group 20.6% (13/63) v placebo group 25.0% (26/104), P=0.5) and from other causes (vaccine group 17.7% (89/502) v placebo group (80/504) 15.9%, P=0.4) did not differ between the two study groups. Conclusion The 23-valent pneumococcal polysaccharide vaccine prevented pneumococcal pneumonia and reduced mortality from pneumococcal pneumonia in nursing home residents.  

Date:

09/03/2010

Rights: Public
Suggested citation:

BMJ. (2010) Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents... [Online]. Available from: http://publichealthwell.ie/node/9884 [Accessed: 3rd April 2020].

  

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