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Cochrane Reviews

Pregabalin monotherapy for epilepsy

Zhou, Q., Zheng, J., Yu, L. and Jia, X. To determine the efficacy and tolerability of pregabalin in people with epilepsy A number of people continue to have seizures and many experience adverse effects, despite current antiepileptic treatments. As a resul ...

Prophylactic antibiotics to reduce the risk of urinary tract infections after urodynamic studies

Foon, R., Toozs-Hoson, P. and Latthe, P. To assess the effectiveness and safety of administering prophylactic antibiotics in reducing the risk of urinary tract infections after urodynamic studies. The hypothesis was that administering prophylactic antibio ...

Safety of regular formoterol or salmeterol in children with asthma: an overview of Cochrane reviews

Cates, C.J., et al To assess the safety of regular formoterol or salmeterol, either as monotherapy or as combination therapy, in children with asthma Asthma is a common condition that affects the airways, the small tubes that carry air in and out of the l ...

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Lawrie, T.A., et al To assess the efficacy and safety of PLD in women with relapsed epithelial ovarian cancer (EOC) The choice of chemotherapy in women with relapsed epithelial ovarian cancer (EOC) is influenced by the duration of the platinum-free interv ...

Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery

Sanders, R.D., et al The authors examined whether short-term statin therapy, commenced before or on the day of noncardiac vascular surgery and continuing for at least 48 hours afterwards, improves patient outcomes including the risk of complications, pain ...

Peritoneal closure versus no peritoneal closure for patients undergoing non-obstetric abdominal operations

Gurusamy, K.S., et al To compare the benefits and harms of parietal peritoneal closure compared with no parietal peritoneal closure in patients undergoing non-obstetric abdominal operations The peritoneum is the inner lining of the abdomen (tummy). After ...

Warfarin initiation nomograms for venous thromboembolism

Garcia, P., Ruiz, W. and Munarriz, C.L. To evaluate the efficacy of a 10-mg warfarin nomogram compared with a 5-mg warfarin nomogram among patients with VTE Venous thromboembolism is the presence of a blood clot that blocks a blood vessel within the venou ...

Vaccines for preventing enterotoxigenic Escherichia coli (ETEC) diarrhoea

Ahmed, T., et al To evaluate the efficacy, safety, and immunogenicity of vaccines for preventing ETEC diarrhoea Enterotoxigenic E. coli (ETEC) is a type of bacteria that can infect both children and adults, causing diarrhoea. In particular, it affects peo ...

Pharmacological agents for preventing morbidity associated with the haemodynamic response to tracheal intubation

Khan, F.A. and Ullah, H. The primary objective of this review was to determine the effectiveness of pharmacological agents in preventing the morbidity and mortality resulting from the haemodynamic changes in response to laryngoscopy and tracheal intubatio ...

Padma 28 for intermittent claudication

Morling, M.R., Maxwell, H. and Stewart, Marlene To determine whether Padma 28 is effective, compared with placebo or other medications, in increasing pain-free and maximum walking distance for patients with intermittent claudication Intermittent claudicat ...

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery

gower, E.W., et al The objective of this review was to evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following cataract surgery Endophthalmitis (inflammation of the inside of the eyeball due to infection or trauma) is a ...

Postpartum misoprostol for preventing maternal mortality and morbidity

Hofmeyr, G.J., et al To review maternal deaths and severe morbidity in all randomised trials of misoprostol for prevention or treatment of PPH Bleeding from the uterus or womb after childbirth is normal, but excessive bleeding (haemorrhage) is an importan ...

Posture and fluids for preventing post-dural puncture headache

Arevalo-Rodriguez, I., et al To assess whether prolonged bed rest combined with different body and head positions, as well as administration of supplementary fluids after lumbar puncture, prevent the onset of PDPH in people undergoing lumbar puncture for ...

Psychosocial interventions for patients with head and neck cancer

Semple, C., et al To assess the effectiveness of psychosocial interventions to improve quality of life and psychosocial well-being for patients with head and neck cancer There is a steady rise in the number of people being diagnosed with head and neck can ...

Routine vaginal examinations for assessing progress of labour to improve outcomes for women and babies at term

Downe, S., et al o compare the effectiveness, acceptability and consequences of digital vaginal examination(s) (alone or within the context of the partogram) with other strategies, or different timings, to assess progress during labour at term For a baby ...

Post-surgical chemotherapy versus surgery alone for resectable gastric cancer

Diaz-Nieto, R., et al To determine whether post-surgical chemotherapy should be used routinely in resectable gastric cancer Stomach cancer is the second leading cause of cancer-related death worldwide. Surgery is the only curative treatment offered to pat ...

Perioperative nutrition interventions for women with ovarian cancer

Billson, HA., et al This review was conducted to assess the effects of nutrition interventions during the perioperative period for women with ovarian cancer Women who have ovarian cancer, (a cancer which develops in the two organs (ovaries) that produce e ...

Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE

Beynon, R., et al To systematically review empirical studies that report the development or evaluation, or both, of methodological search filters designed to retrieve DTA studies in MEDLINE and EMBASE A diagnostic test is any kind of medical test performe ...

Supported employment for adults with severe mental illness

Kinoshita, Y., et al To review the effectiveness of supported employment compared with other approaches to vocational rehabilitation or treatment as usual People with mental health problems experience high rates of unemployment. There are various schemes ...

Supraglottic airway devices versus tracheal intubation for airway management during general anaesthesia in obese patients

Nicholson, A., et al To examine whether supraglottic airway devices can be used as a safe and effective alternative to tracheal intubation in securing the airway during general anaesthesia in obese patients (with a body mass index (BMI) > 30 kg/m2) Pat ...