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Long-term effects of weight-reducing drugs in hypertensive patients

Creator:

Siebenhofer, A., Horvath, K., Jeitler, K., Berghold, A., Stich, A. K., Matyas, E., Pignitter, N. and Siering, U.

Subject Keywords: HYPERTENSION, OBESITY, WEIGHT, BLOOD PRESSURE
Topic: Cardiovascular Health (Draft)
Chronic Conditions
Conditions
Coronary Heart Disease (CHD)
Hypertension
Stroke
Obesity
Chronic Conditions
Obesity
Type: Article
Region: International (other)
Description:

All major guidelines for antihypertensive therapy recommend weight loss; anti-obesity drugs might be a helpful option. Objectives: Primary objectives: To assess the long-term effects of pharmacologically induced reduction in body weight with orlistat, sibutramine or rimonabant on: - all cause mortality - cardiovascular morbidity - adverse events Secondary objectives: - changes in systolic and/or diastolic blood pressure - body weight reduction Eight studies comparing orlistat or sibutramine to placebo fulfilled our inclusion criteria. No relevant studies investigating rimonabant for weight loss were identified. No study included mortality and cardiovascular morbidity as a pre-defined outcome. Incidence of gastrointestinal side effects was consistently higher in orlistat treated vs. placebo treated patients. Most frequent side effects with sibutramine were dry mouth, constipation and headache. Patients assigned to weight loss diets, orlistat or sibutramine reduced their body weight more effectively than patients in the usual care/placebo groups. Blood pressure reduction in patients treated with orlistat was for systolic blood pressure (SBP): weighted mean difference (WMD): -2.5 mm Hg; 95% CI, -4.0 to -0.9 mm Hg and for diastolic blood pressure (DBP): WMD -1.9 mm Hg; 95% CI, -3.0 to -0.9 mm Hg. Meta-analysis showed DBP increase under therapy with sibutramine: WMD +3.2 mm Hg; 95%CI +1.4 to +4.9 mm Hg.

Date:

08/07/2009

Rights: © The Cochrane Collaboration
Suggested citation:

Siebenhofer, A., Horvath, K., Jeitler, K., Berghold, A., Stich, A. K., Matyas, E., Pignitter, N. and Siering, U.. (2009) Long-term effects of weight-reducing drugs in hypertensive patients [Online]. Available from: http://publichealthwell.ie/node/4412 [Accessed: 14th November 2019].

  

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