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Shifting the optimal stiffness for cell migration


Nature Communications

Subject Keywords: Biological processes
Catalogue: Research and Evaluation
Other Outputs
Type: Article
Region: International (other)

Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum â^¼1â??kPa) and U251 glioma cells (optimum â^¼100-kPa). In addition, the model predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphology and F-actin retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and integrin-mediated adhesions.



Rights: © Public
Suggested citation:

Nature Communications. (2017) Shifting the optimal stiffness for cell migration [Online]. Available from: [Accessed: 21st June 2018].


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